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Subsequent studies established a descriptor of STAT1 binding preferences with an improved specificity by defining a position-specific weight matrix (PWM) derived from the in vitro binding of STAT1 to synthetic oligonucleotides [14].
The application of nanotechnology strategies in oncology has revolutionized the transport of drugs to cancer, allowing the appearance of new treatments with an improved specificity.
A further study showed an improved specificity in the spine of patients with different types of primary tumour when using FDG-PET/CT compared with FDG-PET alone.
For CIN2+ as well as CIN3+, that study also found an improved specificity for p16 cytology compared with HPV testing (for CIN2+, 50.7% vs 23.3%).
Similar(56)
For the ROC events alone, a sensitivity of 0.90 corresponds to a clearly improved specificity of about 0.68 (study I) or 0.8 (study II).
These criteria have a high sensitivity of 0.99 and a much improved specificity of 0.79 compared with the previously used diagnostic criteria, such as the Veldman criteria and the Orlando criteria [ 2– 4].
Optimization of the residue at the Z position gave peptides S5− S8 and led to a substantially improved specificity of these peptides (3, panel a bottom).
The ANN classifier demonstrated a much improved specificity over that of the assay CA 125 II alone (87.5% vs 68.4%) while maintaining a statistically comparable sensitivity (79.0% vs 82.4%) in discriminating malignant from benign pelvic masses in an independent validation test using data from the remaining 255 patients which had been set aside and kept blind to the developers of the ANN system.
Further engineering of Hxt11 yielded variants with a dramatically improved specificity towards xylose allowing co-consumption of xylose and glucose at industrial relevant concentrations.
The intervention's odds of improving residents' diagnostic impression were significant (OR = 2.2; 95% CI = 1.3-3.6), with significant improvement in sensitivity (p = 0.02) and a trend toward improved specificity.
Age-specific reference ranges improved specificity in older men (49%) but decreased sensitivity (70%), with an LR+ of 1.38.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com