Such incremental inventions typically include novel formulations, new methods of administration, specialized drug delivery devices, improved dosage regimens, and dosage forms combining more than one active ingredient.
Although it is believed that HBM will contribute to reduced delays in treatment and improved dosage and duration of treatment [ 12], several community and health systems pitfalls have been identified as potential barriers for success of HBM.
With the recent approval of a new drug application for a new concentration, as well as generic formulations, this drug has emerged at the forefront of treatment for actinic keratoses, with improved dosage scheduling and more patients having access to generic options.
The data obtained thus suggest that a microparticulate system can be successfully designed for sustained delivery of Glipizide and to improve dosage form characteristics for easy formulation.
Simulation results showed that recycling and sweeping antibodies can improve dosage frequency and reduce the required dose for target antigens with various clearances, plasma concentrations or binding kinetics.
Results obtained showed an improved flexural strength if high dosage of CaO-based expansive agent is used with metallic fibres.
Results obtained showed an improved flexural strength if high dosage of CaO-based expansive agent is used with either zinc or brass-coated fibers.
The results showed that compressive strength of geopolymers could be improved when dosage of Cr(NO3 3 is small.
These results suggest that the best tetraalkylphosphonium salts could be used as improved low dosage hydrate inhibitors, both in kinetic hydrate inhibitor formulations or as anti-agglomerants, compared to tetraalkylammonium salts.
The aim of this study was to examine whether a multifaceted intervention including the use of a software programme for the estimation of creatinine clearance and recommendation of individual dosage requirements may improve correct dosage adjustment of relevant medications for patients with CKD in primary care.
Most previously published evidence on effective interventions to improve correct dosage adjustment in CKD patients comes from inpatient settings [ 20, 21, 23], even though dosage-related medication errors are equally relevant in outpatient primary care settings [ 40].
