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WGS can also enable more focused contact tracing by reducing the number of plausible genomically linked cases to investigate, leading to an improved case detection.
10 A recent study on trends for pre-eclampsia in Norway 11 also concluded an increase in the condition over the period 1967-98, owing to an improved case ascertainment over time.
Interestingly, case resolution during the second year was higher compared to that of the first year, indicating that greater experience with the management algorithms resulted in an improved case resolution.
Amazon is also offering an improved case, called the Origami, that can fold to hold the device upright or in landscape mode.
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Following the 2008 outbreak, a series of guidelines for the prevention and management of HFMD were implemented in China, leading to an improved case-fatality ratio.
Despite an improving case for the robust treatment effect of weight loss in obstructive sleep apnoea, concerns remain regarding the long term maintenance of improvements, especially after rapid weight loss with a very low energy diet.
Representative clinical images of a typically improved case before and after PBE are shown in Figure 2. In Group 2, there were no significant improvements in scores seen 12 weeks after initial observation as compared with scores before treatment.
There has been a steady increase in esophageal cancer cases in sub-Saharan Africa 5, 6, although it is not clear if this is a real increase or a reflection of improved case detection.
Although most authors have reported a reduction of the positive surgical margin rate as a reflection of improved case selection over time (Stamey et al, 1998; Han et al, 2003), others could not demonstrate this (Freedland et al, 2003).
Health providers' knowledge is an important facilitating factor for improved case detection and patients' timely referral.
Although improved case detection may account for these increases, a true increase in incidence may also be occurring.
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