Exact(1)
However, it is seen that the success of thiophene as an important moiety of medicinal agents led to the introduction of new therapeutic drugs.
Similar(59)
As could be expected for an important nucleosomal moiety and similarly to what we observed with single H3-K56 point mutations [3], the H3-S57 substitutions we studied also induced phenotypes under other stress conditions such as exposure to formamide (Figure 3), and even UV in the case of the H3-K56R-S57E andouble-S57E double mutants (Figure 3).
As an important electronic moiety, isoindigo offers strong intramolecular charge transfer, ICT, an essential feature for small-bandgap donor acceptor systems.
Santalol is a bioprospecting molecule present in sandalwood and any effort towards metabolic engineering of this important moiety would require knowledge on gene regulation.
Catechins are bioprospecting molecules present in tea and any effort towards metabolic engineering of this important moiety would require knowledge on gene regulation.
Maleimide constitutes the important moiety of PKCβII inhibitors, however till date no study on the significance of maleimide toward PKCβII inhibition is performed.
It was certain that the chemical combination of these biologically important moieties would provide a medically advanced class of compounds.
Pyrazoles are important moieties as building blocks for many heterocyclic products and act as abinucleophile [2] with abroad spectrum of remarkable biological activities.
In addition, the structure activity relationship indicated that the (3RS,4RS -configuration between the 3- and 4-position,4RS -configurationat the 3-position, the 9-methylene chain between the scaffold and the sulfoxide moiety, and the terminal perfluoroalkyl moiety play an important role in increasing estrogen receptor binding and oral antiestrogen activities.
Many analyses of synthetic AdA analogues lacking the adenine moiety suggest that the adenine or another aromatic moiety is an important determinant of the high-affinity binding of AdA.
However such a mechanism could provide a solution to the problem of how diverse substrates are accepted if the CoA moiety is an important determinant for recognition and cleavage potentially enables separate permeation pathways for the polar (CoA) and hydrophobic (fatty acid) moieties of β-oxidation substrates.
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