The phrase "an important difficulty in" is correct and usable in written English.
It can be used when discussing a significant challenge or obstacle within a specific context or subject matter.
Example: "One important difficulty in implementing the new software system is the lack of user training."
Alternatives: "a significant challenge in" or "a major obstacle in".
This will help to eliminate an important difficulty in the estimation of LD and genetic relationships between accessions obtained in bi-allelic genotyping studies caused by ascertainment bias i.e. the presence of rare alleles [ 73, 83 85].
An important difficulty in the analysis of proteins is related to their extraction.
An important difficulty in applying these reasoning patterns in practice is that they rely on fine-grained knowledge of how different concepts and entities are semantically related.
An important difficulty in the analysis of HRQoL in stroke patients is that few studies use the same measurement tools and the same period of follow up.
An important difficulty in defining or identifying biomarkers is the evaluation of the endpoint of the actual responses of the patients.
But an important difficulty remains, one not mentioned in the article: a limited supply of affordable helium.
The risks include melting ice sheets, rising seas, more droughts and heat waves, more flash floods, worse storms, extinction of many plants and animals, depletion of sea life and — perhaps most important — difficulty in producing an adequate supply of food.
The point discussed below is perhaps the most important difficulty in establishing (L^2) extension, and the issue arises in other, more elaborate extension problems as well.
Comparison of the case-patient group and the control group revealed the important difficulty in clinical diagnosis: few clinical symptoms differed between case-patients and non case-patients.
Another important difficulty in the implementation is the lack of information: community pharmacists do not have access to routine patient records.
In our context, a qualitative study about the GRADE system showed important difficulties in understanding it and an important level of disagreement among the participating clinicians, with and without previous experience in CPG development [ 14].
