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As an example of what can be learned from this analysis, we studied the motion of two mutants, dop-2 and dop-3, which contain defective receptors for the neurotransmitter dopamine, an important component in the modulation of foraging strategy.
However, the geographic and seasonal variation in salivary gland gene expression discovered in this study must be considered in salivary protein-based vaccine development, as antigen dosage is an important component in the modulation of immune responses [ 66- 69] and immunogenicity and specificity of vaccines [ 66, 70, 71].
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Because proinflammatory responses play an important role in the pathogenesis of bacterial meningitis, their modulation may be an important component in the disease management (for review, see the report by Tauber and Moser [ 10]).
The seed sequence is an important component in miRNAs.
Iron carbide (cementite), Fe3C, is an important component in steel.
Healthy hair is, strangely, an important component in attraction.
Using cell lines derived from human GBM biopsy material and human GBM xenografts, we have shown that regional heterogeneity of oxygen consumption exists in GBMs and that modulation of cellular respiration is an important component of the hypoxia defence mechanisms utilized by GBMs (Parliament et al, 1997; Franko et al, 1998; Allalunis-Turner et al, 1999).
In summary, Noxa and its antagonist Mcl-1 are part of an important component of the mechanisms to re-establish RBC numbers upon blood loss and modulation of this pathway could be envisaged in therapeutic options for treatment of anemia.
None of these three PBPs are essential for growth in their respective organisms, yet modulation of their activities appears to be an important component of the response to compounds that inhibit peptidoglycan biosynthesis.
This is an important component of camouflage in all environments.
In particular, DNA methylation at CpG dinucleotides is an important component of epigenetic gene expression regulation [ 4], resulting in modulation of protein-DNA interactions [ 5, 6].
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