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This might make an importance difference.
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This makes clear that the inclusion of Greece, Spain, and Portugal makes a statistical importance difference.
Identification of a meaningful importance difference threshold was also explored, but the small sample size of responders prevented robust interpretation.
In their study, the authors of the modified Prolo Scale determined the clinical success at 2-year follow-up as excellent 20-177 points), good 16-133 points) and fair (12-9) with a minimal clinical importance difference (MCID) of 3 points.
Difference in PCS scores from the reference category in each set of analysis were defined as a 'Minimal Clinically Importance Difference' (MCID) if the PCS score was 3 points or greater [ 22].
For the primary outcome of NDI, there is consensus that a minimal clinically importance difference lies in the range of 3 5 percentage points, with a standard deviation of about 8%[ 8].
Therefore, we will consider a percentage of importance difference in baclofen effect in the GHB dependent participants of 34% between the Baclofen + TAU group and the TAU only or the matched control group with an expected abstinence rate with baclofen of 70% as in the alcohol studies and of 36% without baclofen.
For the evaluation of the magnitudes of the differences in the outcome scores and whether these were likely to be clinically significant, we used a distribution based method to calculate the minimal clinically importance difference (MCID).
8 The trial was powered to 90% and the minimum importance difference was 10% of cost.
Reliability and validity testing was then performed and the minimally importance difference (MID) explored.
The sample size required and power of the study will be directly related to the minimal importance difference that the researchers wish to detect.
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