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An implicit hypothesis of wet-lab, biomedical experiments, illustrated in Figure 5A, is that attributes of the objects or system of study (e.g. mammalian cells) measured in a particular, controlled experimental context (e.g. in vitro) are quantitatively similar to corresponding attributes in particular humans.
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It is an implicit hypothesis that perturbation of chromatin and epigenetic signatures may lead to alterations in nuclear structure (or vice versa) and that these perturbations lie at the heart of cancer genesis.
(Much of this was apparent 14 years ago [1].) Therefore, the idea that inserted genes exert no unintended damaging effects is an implicit hypothesis which has become an assumption and is now entrenched as a consensus.
Dictated by the design of genotyping platforms or the analysis methodologies, the implicit hypotheses of GWAS and their related implications for future research are summarized in this commentary.
Under such pure-drift divergence models, a strong (and implicit) hypothesis which might often be violated concerns the star shaped phylogeny relating the different populations.
Greater hands-on experience is associated with increased preparedness, supporting the implicit hypothesis which drives the introduction of practice-based placements – that the availability of more hands-on experience will improve preparedness.
One-way ANOVA also provides an implicit test of the null hypotheses that variation within habitats is larger than variation between them, thus providing a test of whether blocks of different habitat types are different enough to justify using them as a surrogate measure of 'resource patches' as used in the previous studies.
The increase of the right posterior MTG activation in our study, as a domain-general social cognitive processes from lower to higher levels9, is consistent with our hypothesis that body movement synchrony is an implicit basis of interpersonal interaction.
The hypothesis motivating this work is that the difficulties from high-degree metabolites arise from an implicit assumption of a narrow metabolite degree distribution, as opposed to the known long-tailed degree distribution.
We have an implicit identical null hypothesis H0: RR i =1 for each area, because of the indirect standardization (Breslow and Day, 1987).
Or would that be an implicit admission of guilt?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com