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It is essential that discussion of such issues be started as early as possible in the patient's course, well before the imperative arises.
"Mapping the Future" includes imperatives arising from decades of data.
Aristotelian virtue and natural justice or the Kantian categorical imperative (arising from reason, of course) offer philosophical bases for morality at large.
Grundfest introduced an imperative hypothesis that neurons arose from ancestral secretory cells.
Applying the categorical imperative, duties arise because failure to fulfil them would either result in a contradiction in conception or in a contradiction in the will.
The major contribution to the nation's GDP from chemistry-related industries will only be maintained through innovation and it is imperative that this arises within the UK if the nation wishes to be one of the main science-based economies.
Reform is an imperative.
We have an imperative.
"Overcoming history is an imperative for us".
"Dansons ensemble!" is an imperative everyone understands.
Finance was an imperative.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com