In brief, our results show here that levels of miR-34a in plasma and PBMCs may serve as a non- invasive biomarker, a circulating 'footprint' of brain aging; in particular the rise in the plasma is detected as early as 4 months of age, before any impending decline in this organ begins.
Contrary to popular opinion, menopause is not a signal of impending decline, but rather a wonderful phenomenon that can signal the start of something positive, such as a good health program.
Running out of luck is often one of the earliest signs of a manager's impending decline, but, at 60, Smith's supply seems to be nowhere near exhaustion.
Therefore, elevated DS may be a prognostic indicator for impending decline in the lifestyle aspects of diabetes self-management, whereas high DRD may predict reduced medication adherence and poor glycemic control.
None of these approaches to identifying frailty, as functional deficit, a composite index, or vulnerability to impending decline, have been well-validated within a medical inpatient cohort.
"These new census estimates are an early signal alerting us to the impending decline in the white population that will characterize most of the 21st century," said William H. Frey, a demographer with the Brookings Institution.
To paraphrase Mark Twain's famous retort about rumors of his death, "Reports of an impending population decline have been greatly exaggerated".
It was not so long ago that the prophets of globalisation proclaimed the impending decline of the nation-state and the rise of a borderless world – one modelled on the frictionless transactions of international finance, which pay no heed to state boundaries.
But even then, he said he heard whispers about his impending decline.
