Clearly, therefore, early environmental 'metabolic imprinting' of a thrifty phenotype, i.e. after maternal undernutrition [16] has the potential to have an enormous impact in the context of the nutrition transition in the Western world [17].
It is one of a number of later social critique stories written by Tezuka that had only a limited impact in the context of his general body of work.
This heterogeneity can have a significant impact in the context of kinetic studies, especially those in which the response is non-linear with respect to the concentration, like the study of immobilized enzymes using protein film voltammetry.
Regardless, the observed elevated mitochondrial protein acetylation in tissues suggests that the function of SIRT3 in suppressing acetylation may have a greater impact in the context of tissues.
An independent but significant factor to these assemblies is read preprocessing, as read error removal has already been shown to have a significant impact in the context of de novo genome assembly (Smeds and Künster, 2011).
What matters is that the numbers make an impact, in context to the community it's trying to serve, no matter how small.
Fahrer said the New Acland mine would result in 234 fewer jobs in the rest of the local regional economy, which he said would have little impact in the context of a population of " a couple hundred thousand".
It is for these reasons that we reject the organic-conventional dichotomy and emphasize that, in order to optimize environmental sustainability, individual tactics must be evaluated for their environmental impact in the context of an integrated approach, and that policy decisions must be based on empirical data and objective risk-benefit analysis, not arbitrary classifications.
We would not restrict future studies to de novo variants, however, because most rare variants are inherited and may have enhanced impact in the context of a 22q11.2 deletion (Stark et al. 2008; Forstner et al. 2013; Schofield et al. 2011; Brzustowicz and Bassett 2012; Merico et al. 2014).
