Our work suggests that cellular de-differentiation is one major oncogenic pathway, a hypothesis based on a numerical description of a cell's differentiation status that can effectively and mathematically interpret some major concepts in V/W theories such as progressive transformation of normal cells, tumor evolution, and cancer hallmarks.
In this paper Valiant introduced the "probably approximately correct" (PAC) model, in which an algorithm posits a hypothesis based on some data set and applies that hypothesis to future data.
A variation of the zebra conundrum: If you have a completely unknown disease but a hypothesis based on some similarities to a few known diseases, how many dissimilarities are enough to toss out your hypothesis?
The main idea of the DS theory is that a recommender attains a certain degree of belief on a hypothesis based on the subjective probability.
I do not however present this as a research article, but as a hypothesis based on theoretical considerations, and am hopeful that scientists that have access to the research tools may try these experiments.
Professor Hopkins, who spent more of his academic life as a sociologist than as a historian, preferred the deductive method, forming a hypothesis based on demographic tables, economic patterns and comparative historical studies, and then seeing how the evidence fit the hypothesis.
In one such effort, Khuda-Bukhsh [ 27] advocated a hypothesis based on many circumstantial scientific evidences and logic that one major pathway of potentized homeopathic drugs could possibly be through regulation of expression of certain relevant genes.
In a scientific experiment, you start with a hypothesis based on what you currently understand about the world around you.
In 1998, a team at the US National Institute of Mental Health proposed a hypothesis based on observation of 50 children that both obsessive compulsive disorder (OCD) and tic disorders may arise in a subset of children as a result of a poststreptococcal autoimmune process.
Currently, a hypothesis based on the presence of an inflammatory process has been has been abandoned and the "epithelial-fibroblastic route" proposed instead to explain disease development [17].
