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Indeed, as reported above, recombination hotspots are fast evolving [ 44, 45] and, therefore, the observed increased segregation of GC alleles in GC-rich regions might have been caused by the presence of an hotspot which is now inactive.
On the other hand, the TCRA locus, which was an hotspot in PBL-GT but did not host any HSC-GT insertions, showed in correspondence to insertion site cluster a strong signal of open chromatin conformation (high H3K4me3 density) in T cells while it is mostly in closed configuration in HSC/HPC.
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It may be a hotspot for A-listers but there's not a pinch of glamour.
In the genome-wide map of all CENP-A hotspots identified in this study, we noted a qualitative clustering of CENP-A hotspots in subtelomeric and pericentromeric regions.
Although 36% of the 942 HeLa CENP-A hotspots correlate with HeLa HJURP sites, only 5% of SW480 CENP-A hotspots co-localize with SW480 HJURP sites.
While navigating toward a Hotspot, indicate an emergency by pressing the button behind your knee for sixty continuous seconds.
The detectability of a hotspot by an observer is correlated with the CNR value of the hotspot.
It is a vibrant place, a hotspot for curry houses, music, art and vintage fashion shops.
In other cases, it is not very straightforward, because, when multiple radiating sources generate a hotspot in a cumulative manner, sources do not coincide with the hotspot position.
Ensure your phone is a mode on a hotspot network.
Turning a Nokia phone into a hotspot [The Reg].
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