Depending on the crystal forms, EfFIC does not form assemblies larger than the dimers (Supplementary Fig. 2a) or forms tetramers related to the NmFIC tetramer (Supplementary Fig. 2b) or forms hexamers comprised of trimers of dimers (Supplementary Fig. 2c), making it difficult to establish the functional oligomeric state based on the crystallographic assemblies.
Legumins are mixtures of trimers and hexamers comprising subunits of 50 60 kDa bound by non-covalent interactions (Hayashi et al. 1988; Shotwell et al. 1988; Wang et al. 2001).
Our data suggest that SpoIIIE assembles a coaxially paired channel for each chromosome arm comprised of one hexamer in each cell to maintain membrane fission during DNA translocation.
HIV-1_0.1.6 uses the larger of two all-atoms models that were refined with molecular dynamics, which stands ∼118 nm tall, but is wider and contains 1356 capsid monomers (216 hexamers and 12 pentamers) comprised of 2 440 800 atoms (PDB entry ; 3j3q).
They are comprised of several thousand copies of a hexamer repeat sequence (TTAGGG n, a single-stranded 3′ G-rich overhang, and a plethora of generic DNA-binding proteins, tankyrases, and specific telomere-binding proteins collectively termed the 'shelterin' complex (Baird 2006; Moyzis et al. 1988; Verdun and Karlseder 2007).
Importantly, miRNA seed matches are disproportionally represented relative to non-miRNA seed matches in the hit lists from Sudbery et al. [ 1]. miRNA seed hexamers comprise around 25% (4 of 16) of significantly scoring seed hexamers, but only around 8% (348 of 4,096) of all possible hexamer words (hypergeometric P-value approximately 9e-3).
The CRAC channel, originally thought to be tetrameric, is now considered to be a hexamer of Orai1 subunits based on crystallographic and electrophysiological studies.
Fibrinogen is a hexamer composed of 2 α, 2 β and 2 γ chains.
The mature pore apparently contains a hexamer of CPE, claudin and, possibly, occludin.
