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Only 1·8% of these patients had an grade ≥3, although 6 (0·4%) patients experienced grade 5 ATEs.
See text for further details In Study 1, while 76% of those without AN responded with a positive SVC only 19% of subjects with AN grade 4 showed a similar response.
In both studies there was an inverse relationship between AN Grade 4 and the SVC response, (P < 0.001).
Figure 1(a) shows that in Study 1 there is an obvious tendency for AN grade 4 subjects to have SVC response of grade 0. This relationship is highly significant (Kendall's tau -0.464,. p < 0.001).
Abbreviations: SVC = Skin vasoconstrictor assay to topical beclomethasone dipropionate; BMI = Body mass index; '*' = interaction Figure 2 shows that in the subgroup with AN grade 4 and the absence of an SVC, CRP was markedly elevated.
The level of hs-CRP was elevated in subjects with AN grade 4.
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A) Grade four and grade five.
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