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Disappointing given the high end specs on the machine (core i7 and up to 32GB of RAM), but perhaps understandable for an extremely complex model.
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This is quite challenging because simultaneous considerations on all MIMO dimensions, channel statistics, multicarriers, and multisymbols lead to an extremely complex modeling and mathematically intractable problem.
In some situations adjustment for centre can lead to an extremely complex analysis model which may not work well in practice.
In its absence, they have been forced to develop ad hoc solutions and data models for importing and representing genome data from Ensembl either directly accessing the raw MySQL datasources (which have an extremely complex data model) or retrieving data from Web Service calls to Ensembl BioMart and converting the raw data to the user's own genetic data model.
For users seeking to fit extremely complex models, this may be a substantial drawback.
We also used a posterior predictive approach (24) for quickly evaluating extremely complex models in which the substitution matrix varied among all the sites (17).
Typically, this has been the domain of government agencies, thanks to their access to this data and the compute power to run the extremely complex models.
In some cases, the software has been heavily customized for supporting non-QSAR models, which range from simple decision trees to extremely complex models combining molecular dynamics with linear interaction energy (LIE) methods [31].
ROS production, detoxification and signalling in the cell is an extremely complex process and the model used here is much simplified.
A macromolecular structure, as measured data or as a list of coordinates or even on-screen as a full atomic model, is an extremely complex and confusing object.
Vasak's model is, of course, a simplified expression of an extremely complex historical record, and it is not intended to suggest a linear process in which each generation gives birth to the next and then dies away.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com