Atherosclerosis and vascular calcification are extremely complex mechanism, with a long list of potential derangements on different pathways, and biomarkers have been extensively evaluated and become an important tool, helping to improve patient care [ 16].
Although the bcl-2 protein prevents apoptosis and in pre-invasive lesions possibly promotes tumour development, in invasive carcinomas alterations in the extremely complex mechanism regulating apoptosis may occur and apoptosis-regulating proteins can be differently expressed and modulated in the different cellular context.
However, little attention has been paid to the extremely complex mechanisms of chemotherapy drug-siRNA pairs during co-delivery process.
Technologies to investigate environmental factors, probe epigenetic phenomena, profile microbes, differentiate and manipulate induced pluripotent stem cells, and directly edit genomes are now advanced enough to decipher the extremely complex mechanisms of buffering human genetic variations.
Cancer is an extremely complex disease process driven by multiple mechanisms involving interlinked signaling pathways.
This may be due in part to the fact that breast cancer is an extremely complex and heterogeneous disease that operates multiple mechanisms of chemotherapeutic response and resistance which are not consistent across different subtypes, particularly in the case of combination regimens incorporating agents that act by multiple mechanisms.
It is clear that the fibroproliferative response to injury seen in this condition reflects an extremely complex interplay between a number of different cellular and signalling mechanisms, with an unknown degree of redundancy.
Unfortunately, the scientific findings to date suggest that an extremely complex pathophysiology underlies Alzheimer's disease with a wide variety of possible mechanisms which may cause synapse loss or dysfunction.
There is an extremely complex relationship between autophagy and apoptosis because they share common stimuli, cellular signaling mechanisms, and regulators.
However, bonding plates to RC structures is an extremely complex engineering problem as research has shown that bonded plates are prone to about 30 mechanisms of failure.
