The phrase "an extreme instance of" is correct and usable in written English.
It can be used to describe a particularly notable or severe example of something.
Example: "The recent flooding was an extreme instance of the climate crisis affecting our region."
Alternatives: "a severe example of" or "a notable case of".
Genes active in one inbred line but inactive in another represent an extreme instance of allelic diversity defined as single-parent expression [4].
This tragic story embodies an extreme instance of mission drift and social harm; however, the risk that less dramatic versions of mission drift will undermine the promise of social finance is endemic and must be mitigated.
That it might also be a transfer of wealth from future taxpayers to incompetent or opportunistic financiers — an extreme instance of privatizing gains and socializing losses — did not trouble the equity markets, which generally don't fret much over fairness.
But the case of handicaps is just an extreme instance of what is always present, namely each individual has a set of traits and natural powers bestowed by genetic inheritance and early socialization, and these differ greatly across persons and greatly affect people's access to valuable ways to live.
Actor Dustin Hoffman's reaction is an extreme instance of Hollywood anger over a bit of Cannon chutzpah.
A recent bombshell Rolling Stone article about an alleged gang-rape at the University of Virginia seemed to show an extreme instance of sexual violence on campus.
A more extreme instance of a polis that was never fully synoecized in the physical sense was Sparta, which, as Thucydides elsewhere says, remained "settled by villages in the old Greek way".
A more extreme instance of a polis that was never fully synoecized in the physical sense was Sparta, which, as Thucydides elsewhere says, remained "settled by villages in the old Greek way". It was an act of conscious arrogance, a way of claiming to be invulnerable from attack and not to need the walls that Thucydides again and again treats as the sign and guarantee of civilized polis life.
This approach may be more appropriate when the association between Y and X is not driven by the longitudinal trend of X or an average level but rather an acute or extreme instance of exposure.
(The most extreme instance of such an approach is undoubtedly the hold-up in L'Argent, which we don't see at all - it's thanks to the soundtrack alone that we know what's going on).
In the extreme instance of Hiss, the "welfare of the university" overrode other considerations.
