The extensive target screen, including 111 targets, did not reveal any hit for the binding site among a number of known receptors or enzymes involved in pain modulation.
We thus performed extensive target gene predictions using the UNION and the INTERSECTION mode offered by the web-based prediction machine DIANA miRGen [42].
Both the proportion of total DCs (0.09±0.04%) and the number (523±254) of DCs per mouse that were Ag+Adj+ were low (Fig. 4C and D), indicating that CAF01 adjuvanticity was not mediated through an extensive DC targeting.
GCHQ was applying extensive "targeting" and "filtering" to the data amassed, the committee said".GCHQ is not collecting or reading everyone's emails: they do not have the legal authority, the resources, or the technical capability to do so".
Treg cells have an extensive and diverse target cell repertoire, and heterogeneous pathways operate depending on the tissue and the identity of the target cell against which suppression is directed.
Since early October, Russia has closed the airspace over north-western Syria as its air force has embarked on an extensive campaign to target the armed opposition to the Syrian leader.
DNMTs have been showed to be an extensive molecular drug target for many available FDA-approved epigenetic drugs such as 5-azacytidine, commercially available as Vidaza, and 5-aza-2′-deoxycytidine, commercially available as Dacogen (Grønbaek et al. 2007; Kaminskas et al. 2005).
We compared drug similarity through a 3D pharmacophoric approach and incorporated similarity data into an extensive source of targets provided by ChEMBL [36] to develop a multi drug-target predictor.
"We've got an extensive list of targets," he replied.
The party has built an extensive modeling and targeting operation, where an individual score is assigned to every voter in a Congressional district, giving strategists the ability to find supporters (particularly those first-time voters who backed Obama) and make sure they cast ballots.
