Sentence examples for an extensive linkage from inspiring English sources

Indeed, except for the regulation of complement activation locus where an extensive linkage disequilibrium block contains CFH and related genes [15], the clustering ranged from 0 2 for both groups of AREDS SNPs.

The design of hypothesis-driven association studies has gradually shifted from studies in which only a few SNPs per gene were investigated to studies employing a more extensive linkage disequilibrium (LD -based approach covering the compLD -basedtic vapproach in a gene or a gene region, incovering for example, regulathey regions.

The MHC is a complex locus with extensive linkage disequilibrium, and an MHC-wide analysis requires larger datasets and specialised analysis methods.

A combination of classical linkage mapping and association mapping allowed us to pinpoint the location of the resistance gene on chromosomal linkage group 2. Examination of the Tvr1 region revealed a relatively high level of nucleotide polymorphism (for a selfing species) and extensive linkage disequilibrium.

To our knowledge, this is the most extensive linkage map of a Malus mapping progeny published to date.

Reducing the extensive linkage disequilibrium present in an F2 population requires breeding additional filial generations by repeated intercrossing, i.e. using F2 individuals to generate an F3 generation and so on, to form an Advanced Intercross Line AILL) pedigree [ 6- 8].

These interference effects are possible because of an extensive genetic linkage across influenza's HA (Strelkowa and Lässig, 2012) and arise from variation in the background fitness of viral strains and from variation in the fitness effects of subsequent mutations.

Morex traces to barley germplasm of Manchurian origin and was used as a parent of mapping populations used for extensive linkage and QTL mapping [ 14].

Interim analysis after genotyping a subset of the total cohort revealed that extensive linkage disequilibrium was present across the four SNPs tested.

While the SNP rs4759021 which displayed the strongest evidence of association with BMD in both scans (ALSPAC: standardized beta =.134, SE = 0.039, P = 0.0006; Australian scan: OR = 2.75, P = 0.001) lies in the gene AAAS, the extensive linkage disequilibrium across this region means that a putative functional variant might lie within any one of a number of different genes.

A region of approximately one megabase of human Chromosome 12 shows extensive linkage disequilibrium in Utah residents with ancestry from northern and western Europe.