In European countries with laws that define a narrow interpretation of "legal representatives," researchers have reported extensive difficulties with enrolling patients in research [9, 48].
In European countries with laws that define a narrow interpretation of "legal representatives," researchers have reported extensive difficulties with enrolling patients in research [ 9, 48].
Nonetheless, we do not expect extensive difficulties as it has recently been shown that a rat ESC line derived in 3i culture medium permits targeting of the Trp53 gene albeit with a low efficiency of 1 4% [ 34].
Though the fossil record of Bovidae and Ruminantia is extensive, difficulties of phylogenetic resolution mean that many topological relationships and phylogeographic reconstructions have come from molecular phylogenies of extant taxa.
The lack of association between neighbourhood deprivation and multimorbidity in this population is likely to be due to area based measures of deprivation not accurately reflecting the relative degree of affluence or poverty experienced by people with intellectual disabilities, in the face of the extensive difficulties they have to cope with in life.
Indeed, many drugs in the medication list may indicate an extensive medical history, and may implicate difficulties to choose the optimal treatment strategy.
It is extremely concerning that non adherence to prescription medications for mental health difficulties is such an extensive problem, and even though a vast array of factors were considered in the current analysis, it was not possible to explain a significant proportion of the variance in adherence versus non-adherence.
This is a standard assumption in this literature despite a number of well-known conceptual difficulties (see Huber 2009 for an extensive discussion of this and related issues).
This study confirms Internet searching difficulties for both specialists and family physicians, with an extensive amount of information to scan, and lack of specificity for available information.
These difficulties increased in the late 1970s, when Miles embarked on an extensive reconstruction of the Mermaid, and a few years later the trustees ordered the theatre's sale.
Mr. Dixon's lawyers have suggested in court that an extensive examination of his past conducted for them by a social worker had indicated learning difficulties and emotional problems.
