The phrase "an extensive decrease" is correct and usable in written English.
It can be used to describe a significant reduction in quantity, size, or degree of something.
Example: "The company reported an extensive decrease in sales over the last quarter, prompting a review of their marketing strategy."
Alternatives: "a substantial decline" or "a significant reduction."
As shown in Fig. 5A C, electroporation of morpholino anti-sense oligos induced an extensive decrease of TUJ1 immunolabelling whereas the control morpholino did not.
The addition of zoledronate to the treatment regimen further decreased tumour burden and effected an extensive decrease in bone-associated soft tissue tumour burden, independent of doxycycline treatment.
The addition of zoledronate to the regimen further decreased tumour burden, caused an extensive decrease in bone-associated soft tissue tumour burden (93%), and sustained the bone volume, which could result in a smaller fracture risk.
EBP1 has been shown to constitutively activate ICAM-1 transcription [ 23], and our current results clearly demonstrated an extensive decrease of ICAM-1 expression in 50/66 ACC tissues.
After 2 h in culture, OATP1B1- and OATP1B3-mediated uptake was observed in all donors, while over longer culture times, an extensive decrease in transport activity, together with an increased variability due to increased passive uptake, was observed (Ulvestad et al. 2011).
The catchment showed a more extensive decrease in vegetation cover than the reserve in areas along major rivers supplying Malilangwe reserve.
During the same time frame, radiography shows a sustained and extensive decrease in osteolytic lesions (van der Pluijm et al, 2005), thus substantiating the primary mechanism of action of bisphosphonates as anti-resorptive.
This is consistent with the extensive decrease of 222 nm peak intensity observed in Figure 4i.
GX-FBA simulations predict that interaction with Chloramphenicol leads to extensive decrease in nitrogen metabolism of the cell.
The extensive decrease in the baseline expression of AREG/EREG proteins in the A431 cells remaining after acute short-term treatment with Ctx was noteworthy.
Staining of tissues collected 24 h after treatment displayed extensive decrease in E-cadherin and increase in ZEB1 and vimentin in surviving tumor adjacent to the thermal injury compared with control (Fig. 7, control and thermal ablation treated).
