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To this extent, we have analysed coevolution patterns in an extensive alignment of more than 6000 non-identical Influenza A neuraminidases to eventually identify connected networks of residues using the SCA algorithm [ 38] as implemented in [ 39], but no network that would connect the surface directly to the core and catalytic site was found (see supplementary material).
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Additional File 1: Provides an updated tree showing the relationship of the ATP grasp modules, a more extensive alignment of the R2K clade, its phyletic distribution, and its gene neighborhoods.
After the analysis of a more extensive alignment, the most informative Swissprot hits were selected.
The kinase aficionados would probably appreciate a more extensive alignment.
If so, a more extensive alignment of the amino-acid sequences would be needed to assess the homology inferences at each of the intron-containing sites.
We estimated a value of 0.5 s for τ, which described the measured transition of SF alignment from essentially no alignment at 0.01 Hz to extensive alignment at 1 Hz.
Comparison of bin-mapped wheat ESTs [14] with mapped Brachypodium BES identified extensive alignment of some large contigs with wheat chromosomes.
The ycf1 gene was not used due to extensive alignment ambiguity.
In this way, using our extensive alignment and the methodology described by Schmidt et al. (2001), the set formed by the aligned codons from the three mtDNA-encoded COX subunits (ABC) was split into two subsets: ABCMt nu_Contact and its complement, (ABCMt nu_Contact c.
Early extensive alignment efforts between investigators and key users on the formulation of the research question using previous experience and researchers' knowledge, exploring the actual needs behind the question, and taking into account study limitations is important to manage the expectations on the contributions and achievable timelines at both sides.
Author's response : This section has been revised and much more extensive alignments are presented and phylogenetic analysis performed.
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