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As we talked about it, I had this epiphany: in any story, madness (like magic, murder, etc). is first and foremost a literary trope rather than an expression of objective psychological reality.
Please note that "great" here is an expression of enthusiasm and not an objective measure of quality.
To assess the effect of a target gene knockout on the expression of objective genes in a certain predetermined brain structure s, we calculated the change in levels of expression of the objective genes R s T, by averaging R p T for all spatial points of the brain structure s.
This information was used to predict the effect of a knockout of target genes on the expression of objective genes in given brain structures.
F C s T value clearly reflects the structure specificity of the knockout effect of the target gene on the expression of objective genes, but it has a drawback.
Analysis of the models showed that for the 15% of target genes a pronounced structure-specific effect was observed on the expression of objective genes involved in the GO category "apoptotic process", for a variety of anatomical structures of the brain.
It turned out that among the examined target genes some showed a pronounced structure-specific effect of their knockout on the expression of objective genes in distinct anatomical structures of the brain according to created models.
Since the fuzzy variables in the RMA model are usually continuous variables and the exact analytical expression of objective function cannot be obtained, traditional optimization algorithms cannot be used to solve it.
One of the main advantages of simulation-based optimization is that it not necessary to provide analytical expression of objective and constraints function as in the case of mathematical optimization.
These models were used to assess the knockout effect of target genes on the expression of objective genes.
To investigate the spatial distribution of the knockout effect of target genes on the expression of objective genes, we examined the main anatomical structures in a hierarchy represented in base Allen Brain Atlas.
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