The phrase "an explanation for the defect in" is correct and usable in written English.
You can use it when discussing the reasons or causes behind a specific defect or issue in a product, process, or system.
Example: "The engineer provided an explanation for the defect in the software that caused the system to crash unexpectedly."
Alternatives: "a rationale for the flaw in" or "a justification for the issue in".
These results rule out the role of endocytosis as an explanation for the defects in clu mutants.
Zhao et al. have reported that AGEs inhibited cytochrome c oxidase and ATP production; this could be a possible explanation for the defect in insulin secretion.
The de-repressed expression of Elf5 in basal cells also allows us to provide an explanation for the nursing defects observed in our Runx1 conditional knockout mice (via a potential Runx1-Elf5-Snail2 link in basal/myoepithelial cells).
This assay demonstrates that RASSF7 is a key regulator of microtubule growth and provides an explanation for the spindle defects seen in mitosis.
A plausible explanation for the defects in cerebellar foliation of the PEX13 brain mutants is the impaired migration of granule cells and abnormal Purkinje cell development.
Consistent with this hypothesis, ATP levels in pink1 B9 mutant flies are reduced compared to controls (Clark et al, 2006), providing an explanation for the neuronal defects we observe in pink1 mutants.
Activation of mitogen activated protein kinases (MAPKs) and protein kinase B (PKB; also known as AKT) was impaired in bone-forming cells of MSC SHP-2 KO mice, which provides an explanation for the skeletal defects that developed.
These data suggest an impairment in synaptic function at the NMJ due to overexpression of TDP-43 in motor neurons and provide an explanation for the larval turning defect shown in Fig. 5H.
The subtle differences that have been uncovered between Sar1A and Sar1B in these studies might also provide an explanation for the molecular basis of the defect in CMRD.
In Runx1-null mice, upregulation of Elf5 in basal MECs may lead to repression of Snai2, which may provide an explanation for the similar nursing defect we have observed in our Runx1 conditional knockout mice.
