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These are the two cases in which we feel confident in asserting a common function between two proteins; the first reflects an expert assertion, and the second an instance in which divergence is minimal.
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The process of integrating what is known from the literature into a set of expert assertions involves highly complex decisions and is well beyond most of the common bioinformatics tools.
In an initial stage, an expert in a biological topic integrates what is known from the literature producing a set of expert assertions, which include the assertions from the literature, as well as a far broader set based on judgement and extrapolation.
v. AGA Medical Corp., 717 F. 3d 941, 941 (CA Fed. 2013) ("conclusory expert assertions cannot raise triable issues of material fact") (collecting cases); Mid-State Fertilizer Co. v. Exchange Nat.
If Three Mile Island jolted Americans, another such external event has been the unharmonious chorus of expert assertions that the chances are increasing that the bomb may actually be used.
The more comprehensive and well structured the collection of expert assertions, the more rapidly accurate projection technology will be developed.
On the other hand, there is every reason to believe that fully automated tools can be developed to project these expert assertions.
One technology for creating and maintaining expert assertions was developed within the context of The Project to Annotate 1000 Genomes [ 10].
2. Bioinformatics tools are developed to project structured collections of expert assertions (rather than just the wet lab results captured in the literature) to new genomes.
Here it is worth noting that we speak of "well-structured" sets of expert assertions, since the developed tools will almost certainly need to encapsulate numerous rules covering special cases, and a careful delineation of these rules can best be achieved by domain experts.
It arose from an extraordinary assertion by an expert witness in the death penalty trial of Duane Buck, who was convicted of the 1995 murders of a former girlfriend and one of her friends while her young children watched.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com