The decision that must result from the solution of the MCO problem can be stated as "a selection of those genes that show the highest possible expression change in all experimental instances when considered simultaneously".
However, the task of reverting a cancer cell to its normal state, in response to differentiation signals, has been only reached in a very few clinical or experimental instances (for review, [1]).
When evaluating screening result, one needs to bear in mind that the connectivity score is merely a statistical measure of similarity or dissimilarity, as it is easier to obtain higher connectivity scores in a relatively low number of experimental instances.
In this paper, we propose an enabling computational and theoretical framework for the analysis of experimental instances of collective behavior in response to external stimuli.
To evaluate the efficiency of the proposed algorithm, some experimental instances are generated and solved.
Specifically, coefficient tuning from experimental instances of NSV are considered to identify the unknown coupling coefficients in the van der Pol model.
Proper orthogonal decomposition (POD) CFD techniques and coefficient tuning from experimental instances of NSV have been considered to identify the unknown coupling coefficients in the van der Pol model.
Nonetheless, already in its present form, or after suitable improvements (e.g. optimisation of steps specific for PrPSc visualisation), the assay may well be valuable for different experimental instances.
No less than three independent experimental instances have been performed for each unique experiment.
Additional file 1: List of experiments used in SLiM discovery as recorded for experimental instances in the ELM database.
It can easily be verified that in all the experimental instances, the CAMPways alignments are superior to those of the SubMAP.
