While we expected activation of translation as a function of eIF4E induction, the large number of genes whose translation was repressed after eIF4E induction is surprising.
As expected activation of the ISG response during C. pneumonia infection was dependent on these kinases (Fig. 3A).
As expected, activation of HIF-1 by S. aureus 8325-4 and the S. aureus ΔhemB hemB-complemented strain did not occur in gas-permeable culture dishes and this correlated clearly with the oxygen partial pressure in the respective cell culture supernatants.
As expected, activation of the ERK1/2 pathway by H2O2 was blunted in the presence of U0126.
As expected, activation of TG6 requires Ca2+-binding and TG6 was found to display a similar concentration-dependence for activation as TG2 (Fig. 1e).
As expected, activation of c-Myc for 14 days triggered the progression of papillomatosis with marked epidermal hyperplasia, dysplasia, angiogenesis, and formation of nucleated cornified layers (parakeratosis).
Administration of HRGݱ alone induced the expected activation of ErbB-3 and -4, ERK1/2, and AKT, although the effects on proliferation were varied.
As expected, activation of S6K1 signaling (measured by S6K1-T389 phosphorylevels levels and S6-S235/236 levels) was inhibited by rapamycin under this condition (Fig. 7C).
Therefore, as expected, activation of EGFR signaling in vascular SMCs is implicated in enhanced neointima formation observed in Mig-6 knockout mice.
