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One mechanism of AR reactivation is somatic mutation of the AR (estimated to occur in 8 25% of recurrent tumors), where specific mutations of the ligand binding domain render the receptor responsive to an expanded host of ligands (Suzuki et al. 1993; Veldscholte et al. 1990, 1992a, 1992b; Zhao et al. 2000).
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Genotypes 1 and 2 are restricted to humans, and genotypes 3 and 4 have an expanded host range and are capable of causing zoonotic disease (6 – 10 ).
Over the past few months, the accelerator has continued launching funds in Southeast Asia, Istanbul, Japan and others joining their expanding host of initiatives abroad.
One way to tease apart these hypotheses is to test the underlying assumptions of selection for expanded host use across systems.
Considering the economic importance and seemingly continually expanding host range of the Harveyi clade (Austin et al., 2005; Rosenberg et al., 2007; Cervino et al., 2008; Defoirdt et al., 2008), there remains a continued interest in the development of methods to identify and differentiate its members.
Part of the plan entailed expanding host opportunities in communities of color.
These include expanding host inoculation tests with a wider range of isolates, examining the ability of indigenous flora to support sporulation on asymptomatic foliage, and survival of P. kernoviae in roots and soil.
Pathway analysis identified the rapidly expanding host immune response with 62 of the 124 (50%) genes in this cluster associated with "inflammatory disease".
Detection of these viruses in humans outside of China highlights the necessity and urgency for comprehensive surveillance because of the viruses' expanding host range.
In the last year, Oakland schools have introduced and expanded a host of programs, some federally subsidized, to feed students at school and home.
Combined with the recent work on IL-17 and Th17 cells in mice, this has led to an expanded understanding of the mechanism of host defense from C. albicans at mucosal surfaces and the role of IL-17 in immunity from infection.
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