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Later on, the SBA was improved using rabbit serum (rSAB) as an exogenous complement source.
An in vitro opsonic reaction is initiated when bacterial cells, human serum (heat inactivated to abrogate endogenous complement activity) containing functional antibodies to the bacteria, and an exogenous complement source are mixed together.
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The primary objectives of this study were to demonstrate non-inferiority of the MenACWY-TT vaccine over the MenACWY polysaccharide vaccine for the entire population in terms of vaccine response (measured by a serum bactericidal antibody assay using baby rabbit serum as exogenous complement source [rSBA]) and incidence of any grade 3 general symptom reported within four days after vaccination.
This phenomenon occurs without exogenous complement and requires no pre-treatment of target or killer cells.
Studies during the 1960s showed that adults with naturally acquired SBA titers ≥1 4 (using human serum as exogenous complement source) were protected from MenC disease.
After this period 50 μL of exogenous complement (guinea pig serum 10% in Hanks' solution) was added to each tube and incubated at 37°C for 30 min.
Both rabbit and human complement have been used as the exogenous complement source; there is currently no international consensus on the standard source of human complement to be used.
Sera were analyzed to assess complement-mediated serum bactericidal antibody (rSBA) levels using baby rabbit complement as an exogenous source.
Thus, T is an exogenous variable.
Furthermore, motherhood is an exogenous state in our model.
Of course, divorce risk cannot be considered an exogenous shock.
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