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The earliest surviving monument of Spanish literature, and one of its most distinctive masterpieces, is the Cantar de mío Cid ("Song of My Cid"; also called Poema de mío Cid), an epic poem of the mid-12th century (the existing manuscript is an imperfect copy of 1307).
In one of his few existing manuscript letters, Vespucci tells of his decision to write an account of his most recent voyage so he can leave "some fame behind me after I die".
The modality dates back, at least, to the medieval period when the technology of textbooks was introduced into the classroom where, traditionally, the professor read to the students from the only existing manuscript.
If electrophysiological data are available then we would propose to include them in the existing manuscript.
Overall, there was considerable enthusiasm for the MorphographX resource, but it was felt that its broad utility as a resource is dependent on making several additions, modifications and consolidations to the existing manuscript and accompanying software and documentation.
The existing manuscript does allude to this in the subsection "Myosin 15 isoforms are differentially trafficked within the hair bundle": "This indicates that the majority of myosin 15 in the second row is isoform 1 and that isoform 2 is the minor species at this location".
Although this question was first explored by Buckles (2005), we believe that our paper contributes in a substantial way to the few existing manuscripts that address this topic by using more adequate data and methodology.
This is based on an anonymous ancient scholiast's annonations to one of the existing manuscripts of Aeschines's works.
He probably selected this particular alphabet from existing manuscripts as the best one to use in copying new manuscripts.
The existing manuscripts posed problems even for them, not the least being Bach's penchant for writing outside the range (or what we think was the range) of the 13-course Baroque lute.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com