The Binary Kernel Discriminant (BKD) is an example of a method which uses information from inactive molecules.
An example of a mutation resulting in folded but inactive protein is the change of aspartate 122 to asparagine (D122N).
An example of the reactivation of a gene on the inactive X chromosome in lupus CD4+ T cells is that of CD40 ligand (CD40LG).
An example of this ligandin role is the specific binding of GSTP1-1 to Jun-kinase, a pro-apoptotic enzyme that becomes inactive when bound to GST.
An example of work to synthesize the curated and uncurated data is Mervin et al. [15], where a dataset with ChEMBL active compounds and Pubchem inactive compounds was constructed, including inactive compounds for homologous proteins.
The investigators chose 30, looking for the most extreme examples of inactive people.
The team trawled the salmon genome for examples of inactive transposons, then eliminated apparent mutations.
This observation is illustrated by several examples provided in Figure 2. Figure 2 Examples of inactive or poorly active (% inhibition < 20% at 10 μM) compounds 2. These SAR observations are useful in determining the 'activity' chemistry space for future optimization of the series.
If insulation at these boundaries is defective, as observed after chromosomal rearrangements, for example, a spreading of inactive chromatin modification into the active chromatin is observed; a phenomenon called position-effect variegation (Probst et al. 2009).
This often results in activation of the secretory protein, an example being the conversion of inactive proinsulin to active insulin by removing a series of amino acids.
