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An example of a transversion occurs in tRNAAsp GTC).
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One single nucleotide polymorphism was identified at the 7th nucleotide of intron 18 consisting of a C to A transversion.
This ratio accounts for the bias of G → T (C → A) transversions and allows us to relate different types of mutations to the G → T transversions.
For example in figure 2, the expected number of A to C transversions will equal the expected number of A to T transversions between the root and taxon 1.
In exon 6 of DLD1/HCT15, a C to A transversion caused a leucine-to-methionine substitution at residue 248 (L248M).
This first-level approximation does not take into account A → T (T → A) transversions (although these mutations have been observed experimentally (Dizdaroglu 2012), due to the lack of an experimentally observed ratio relating A → T transversions to A → C transversions.
For example, a C-T transversion at position 303227 (wrt 2122/97) within the coding sequence of nirB of 1307/01 is a sSNP that appears to be linked with the upregulation in expression of nirB within that strain.
Gpg6 mice show a T to A transversion in exon 3 of Atmin, correlating with the third Zinc Finger.
For longer branch lengths, the greater frequency of transitions than transversions increases the likelihood that a site will have experienced two transitions, inferred as one, while a site with a transversion has a single substitution.
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