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More poignantly to the current findings, we exploited an evidence network with a prevalent star shape.
This comparison was only possible through inclusion of observational studies as an evidence network restricted to RCTs would be disconnected.
In the Results section, we illustrate the influence analysis and the decomposition of an evidence network into independent paths based on the antidepressants example.
We discuss this tool for consistency and influence assessment in contrast to the net heat plot [ 10] by using an evidence network of twelve antidepressants.
Firstly, as no across-study covariates were included, we applied our final NMA model to an evidence network which included the studies which were excluded due to non-reporting of covariates.
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22 Currently, it is not clear by which mechanism industry sponsorship bias would operate, and how it would influence a complex evidence network including a large number of placebo controlled and active comparator trials.
We consider a network meta-analysis for T+1 treatments A0,…, A T that are compared in a set of studies building a connected evidence network as for instance shown in Figure 1.
A secondary evidence network of drug class will also be constructed to view the group psychotherapy or individual psychotherapy in the same intervention as a separate node.
In circumstances where randomised evidence between all relevant comparators is unavailable, network meta-analysis combines evidence from trials comparing different sets of treatments that form a connected evidence network through common comparators, in this case placebo.
A secondary evidence network of drug class was also constructed, to compare the effects of direct thrombin inhibitors (dabigatran and ximelagatran), direct Xa inhibitors (rivaroxaban and apixaban), VKA (excluding low dose), ASA 100 mg daily, and placebo or observation.
Thus, we suggest conceptualizing a practice-based evidence network not as a traditional registry but as an endeavor that is explicitly focused on outcomes evaluation, guided by a research framework to identify key questions and ensure that relevant data are captured.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com