Importantly, once global alterations of LV architecture and function are established, progression to CHF with functional deterioration and eventually death is inexorable [ 82].
AID is an established disease progression factor in many cancers.
It can help establish progression curves of intraepithelial neoplasia (IEN) to invasive cancer, and thus detect chemopreventive effects.
When you enter the workforce, you'll find that most organizations (particularly larger ones) have an existing structure, and an established path for progression; steps in your career path that lead to titles...that correlate to responsibilities...that lead to...well, more steps.
Obesity is an established risk and progression factor for many cancers.
The prevalence of obesity, an established risk and progression factor for breast and many other cancer types, remains very high in the United States and throughout the world.
These pathways play an important role in the pathogenic processes of kidney disease, mediating immune, inflammatory and proliferative effects that culminate in progressive renal damage [ 12]. 25(OH D deficiency may potentiate the decline in renal function as well as the progression of albuminuria, which is in itself an established predictor of CKD progression and cardiovascular outcomes [ 13- 15].
S100beta is an established biomarker of disease progression; however, the mechanism of its regulation in melanoma is undefined.
Indeed, β-cell function relative to insulin sensitivity, the DI, is an established metabolic predictor of progression to diabetes (13, 31).
The DI, which expresses β-cell function relative to insulin sensitivity, is an established metabolic predictor of progression to diabetes (12, 13, 29– 31).
Although an established role in tumor progression has been attributed to macrophages and dendritic cells, the role of infiltrating neutrophils is less well defined [ 4– 6].
