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While Neosaxitoxin and Gonyautoxin, another Paralytic Shellfish Poison (PSP) toxin, have been successfully used in humans as long-lasting pain blockers, this finding marks the first time a PSP has been shown to have an established effect in veterinary medicine.
Hence, heparin-induced changes of the activation current at fertilization [25], [48] may have caused the increased frequency of polyspermy, which is an established effect of heparin, as a result of the failed 'electrical block.' The fast blockade of supernumerary sperm entry by this mechanism of fertilization membrane depolarization has been also reported in starfish eggs [5].
Nevertheless, screening results in an established effect, i.e. the increased frequency of smaller tumour size at the time of diagnosis that has been observed in every trial that has been conducted.
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Psychosomatics represent an interaction between psychic and physical aspects with the former having an establishing effect on the latter.
For an already established effect, it is often relevant to test if the effect increases across the studied dose range to evaluate the benefits and risks for one dose level against another.
Stimulus specific adaptation, representing a reduction in neural activity in response to repeated stimulation, is a well established effect.
To investigate these mechanisms further, and to enable use of bryostatin for prolonged periods, the effect of a vasodilator on the established effects of bryostatin on calf metabolism was studied using 31P magnetic resonance spectroscopy and near infrared spectroscopy.
But resurrection is already an established special effect in Hollywood.
Moderate- to vigorous-intensity physical activity (MVPA) has an established protective effect against a range of such outcomes and associated risk factors, including obesity.
Second, the study by Schmid-Elsaesser and colleagues [ 4] compared magnesium sulphate infusion with nimodipine, the latter of which has an established beneficial effect on aneurysmal subarachnoid hemorrhage.
The candidate colon cancer protein space that is targeted by plants with an established phenotypic effect against colon cancer allowed us to get a better insight on the biological and network properties of these 79 proteins.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com