While under-reporting is a well established challenge of passive surveillance systems, the problems associated with NHP ADR monitoring are more complex than those associated with pharmaceutical drugs.
The experience of the past half century suggests that the Court cannot produce social reform on its own, and that judges are unlikely to challenge an established social consensus.
A challenge to an established gang seems to have been behind the violence in Pedrinhas.Brazil's criminal code includes neither the death penalty nor a life sentence.
Yet while spirits were high, there was an air of uncertainty about how Karanka's team would stand up to the challenge of an established Premier League side full of international quality.
Allergen challenge is an established asthma model with features of both an early, predominately mast cell mediated, and a late asthmatic response driven by a more complex inflammatory response characterised by eosinophilic inflammation.
There is the impression of playing catch-up, as there is not yet an established mechanism to anticipate the challenges of the future.
The fact that this manifesto was made at St Anne's, a college established to challenge women's historical exclusion from Oxbridge, adds irony to insult.
May 6 is International No Diet Day, a day established to challenge the cultural attitudes and values that contribute to chronic dieting, weight preoccupation, eating disorders, and size discrimination.
Altogether, our data suggest that PTEN deleted tumors expressing low levels of AR may represent a worse prognostic subset of PCa establishing a challenge for therapeutic management.
The work "challenges an entirely established concept, in a very elegant way".
