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In fenretinide-treated cells, ROS signaling may represent an essential stimulus at the early stage of programmed cell death.
This mechanism, in which extracellular Wnt ligands provide an essential stimulus for cell proliferation, is distinct from that commonly found in human colon cancer and several other forms of cancer, in which constitutive activation of Wnt signaling is a consequence of mutations in downstream cytoplasmic elements such as APC, CTNN1 (encoding β-catenin) or AXIN2 [3].
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In the latter case, senescence was usually produced by the removal of an essential oncogenic stimulus or the restoration of a tumor suppressor.
When the economy was imploding only three Republican senators voted for the absolutely essential stimulus bill; none agreed to back health care reform or even vote to end a filibuster.
However, ADP is the only platelet agonist that stimulates Gαi signalling at physiological concentrations and is therefore an essential co-stimulus to achieve full functional responses for all known platelet agonists (Dorsam & Kunapuli, 2004; Gachet, 2008).
Thus, the stromal (fibrotic) compartment in the MG may provide the essential stimuli for the transition of N-cad from its adhesive to an oncogenic function.
An Engels quotation loomed over a set of wooden display cases: "First labor, and then speech these were the two most essential stimuli under the influence of which the brain of the ape gradually changed into that of man, which, for all its similarity, is far larger and more perfect".
Instead, instability exercises accounted for increased activity in the stabilizing muscles and, thus, provide essential stimuli for their neuromuscular adaptation [ 6].
Obama should put his full weight behind the Employee Free Choice Act as an essential part of his stimulus package.
One type of physiological response to a novel stimulus, an essential component of the orienting response, is heart rate deceleration (Bolls et al. 2001; Leshner et al. 2009).
Clearly, Food Stamps are an essential part of the stimulus.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com