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MCM4 and MCM7 are the part of MCM protein family, which play an essential roles in initiation of DNA replication [ 36, 37] and may be pre-cancer markers [ 39].
Using targeted gene inactivation in the mouse, different studies support the hypothesis that NRG-1 plays an essential roles during development of the heart and peripheral nervous system and demonstrates that the main NRG-1 receptors in vivo correspond to ErbB2/ErbB4 or ErbB2/ErbB3 heteromers, respectively (for reviews, see [ 105, 106]).
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