The phrase "an essential role however" is not correct as it stands and may cause confusion in written English.
It can be used when you want to emphasize the importance of a role while contrasting it with a previous statement, but it needs restructuring for clarity.
Example: "The project faced many challenges; however, an essential role was played by the team leader in guiding us through."
Alternatives: "a crucial role nonetheless" or "a vital role, on the other hand".
Beclin 1 plays an essential role in autophagy; however, the regulation of Beclin 1 expression remains largely unexplored.
The core autophagy machinery comprising 18 autophagy-related (Atg) proteins in yeast plays an essential role in autophagosome formation; however, the molecular role of each Atg factor and the mechanism of autophagosome formation remain elusive.
These cytokines are type 2 immune response-related, and it therefore appears that Th2 cells and ILC2s might play an essential role in this pathology; however, CD4+ and CD8+ T cells are known not to be involved in the pathogenesis of PSP (Kwon et al., 2013).
However, an essential role in histidine biosynthesis has undoubtedly selected for maintenance of hisA.
We hypothesize that MIF might play an essential role in normal bone remodeling; however, over-expressed MIF might have an osteoclastogenic effect on bone metabolism in inflammatory diseases.
These results were consistent with an essential role of H1 in global chromatin function; however, they were in contrast to data obtained in the ascomycete Aspergillus nidulans, where deletion of the H1 gene hhoA did not result in an obvious phenotype (Ramon et al., 2000).
Physicians have an essential role in the sickness absence process; however, there is very little scientific knowledge about this.
Evaluations of multiple aspects of platelet function including assessments of inside-out and outside-in signalling through integrin αIIbβ3 and secretion from α and dense granules did not identify an essential role for Rif in mouse platelets, however.
Sequence variation plays an essential role in functional renovation of genes, however, the relationship between DNA variation and functional consequence has been enigmatic for the vast majority of genes in plant and animal kingdoms, despite an increasing number of studies have been reported.
Other studies, however, suggest an essential role of p53 in the response of tumour cells to HDACi treatment (Henderson et al, 2003; Joseph et al, 2005; Kim et al, 2006; Condorelli et al, 2008; Hacker et al, 2011; Bajbouj et al, 2012; Meng et al, 2012).
