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After 10 years of activities, NORMAN has become an essential network in support of EU policies.
A number of royal castles, from the 12th century onwards, formed an essential network of royal storehouses in the 13th century for a wide range of goods including food, drink, weapons, armour and raw materials.
Following this notion, mutating a hub protein of an essential network is most likely to have negative fitness affects.
Such protein level differences can then be used directly to determine how physical and historical constraints shape the system's evolutionary trajectory, if this protein also functions in an essential network of the cellular system.
Although an essential network maintains global information processing to ensure organismal survival, the failure of one node (member of a network) may directly disturb another node or possibly the whole network.
Even though the main structure and function of an essential network may be conserved among divergent species over history, the individual components of the network may exhibit divergent properties [ 6].
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The top 10% of PPI network nodes ranked for both "degree" and "Bottleneck" scores were used to evaluate node "essentiality" [ 15, 84] and to generate a minimal essential network (MEN) (Additional file 2: Figure S5).
A minimal essential network represents the most functionally relevant element of an interactome model and therefore was used to assess biological function [ 15, 16, 66].
The top 10% of nodes, ranked by connectivity and bottleneck properties were selected to generate a minimal essential network (MEN).
The top 10% of this protein:protein JIA Interactome was used to generate a minimal essential network (MEN).
The JIA interactome was then ranked for both connectivity and bottleneck properties and these were used to evaluate the relative importance of each node [ 35, 36], and to generate a minimal essential network (MEN) [ 33, 37, 38].
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