Two essential examples include the recent publication of work identifying a role for Smurfs in regulating Drosophila Ptc turnover (Huang et al., PLOS Biology, 2013), and work from Tom Kornberg that defined a role for the PPXY motif in regulating the turnover of vertebrate PTCH1 (Kawamura et al., JBC, 2008).
We need to give two essential examples, the second of which is crucial to the strategy of this paper: 1.
Nowadays, there is evidence that these polymorphisms have a relationship to such diseases or conditions where vitamin D has an essential role, for example, bone mineral density, osteoporosis and cancers of the breast and prostate [ 11– 13].
For example, an essential issue is not what subjects can consent to but what investigators can ethically ask subjects to do.
Support for abortion rights and gay rights, for example, is an essential litmus test for Democratic presidential candidates.
Iron, for example, is an essential element and is sometimes given therapeutically; if taken in overdose, however, it can be lethal.
Memory is another example of an essential biological function which seems to be supported by multiple brain systems.
The subject of data security, the subject of encryption, for example, is an essential topic, especially in Germany.
Nevertheless, Bolzano argues, there is an essential difference between the two examples insofar as Σ1 is the objective ground for S1, and S1 is therefore entailed by Σ1, whereas this is not true for <Σ2, S2> (RW I, 13 f., WL II, 341, WL IV, 15, 32 34, 261 263, 385 ff., 493, 580 f).
Equality before the law also became an essential component of successful societies – for example, much more present in the United States than in Mexico.
