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The phrase "an essential difference" is correct and usable in written English.
It can be used when discussing a significant or fundamental distinction between two or more things.
Example: "There is an essential difference between a leader and a manager in terms of their approach to team dynamics."
Alternatives: "a fundamental difference" or "a crucial distinction".
Exact(60)
There is, however, an essential difference.
And one sentence sums up an essential difference.
There is however an essential difference between Twitter and Weibo.
Sutcliffe sees this as an essential difference between his films and those of more mainstream media.
There is an essential difference, however, between power networks and communication networks.
The highlight was Eric Gates's sensational second goal, which seemed to reflect an essential difference in class between the sides.
That there is an essential difference between the viewpoint of Anglo-Saxon and Gaul is certain.
Nevertheless, there is an essential difference between the two approaches in the procedure for obtaining the strain energy function.
Nigel Jarrett Abergavenny, Monmouthshire One thing none of your commentators seemed to have mentioned is an essential difference between a web newspaper and a paper copy: serendipity.
Before Darwin decisively quashed the myth of an essential difference, "a century or two ago, in many communities, animals and humans were cared for by the same practitioner".
Mr. Gibbs maintained that this is an essential difference between an instant runoff (a term he views as a misnomer) and a regular runoff.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com