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CH is required for the biosynthesis of phosphatidylcholine, an essential cell membrane component.
Filamenting temperature-sensitive protein Z (FtsZ), an essential cell division protein, is a promising target for the drug discovery of new-generation antibacterial agents against various bacterial pathogens.
Macrophages play a pivotal role in the hosts response to biomaterials being considered as an essential cell type during both optimal tissue-implant integration and pathologic process of implant failure.
The par-titioning-defective or PAR proteins comprise the core of an essential cell polarity network that underlies polarization in a wide variety of cell types and developmental contexts.
The regulatory mechanisms prevent both unconstrained growth (cancer) and decay of an essential cell type.
Actin remodelling into lamellipodia, filopodia and stress fibers is an essential cell response component required for cytokine-induced cell migration [17].
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RUK encodes an essential cell-cycle-regulated 152 kDa protein with a putative serine/threonine kinase domain and a large microtubule-binding domain, both of which are largely conserved in uncharacterized proteins from protozoa, plants, and animals.
Moreover, Vang and Fz do not play an essential cell-autonomous role to orient the mitotic spindle and specify the position of the 'anterior' domain that recruits Pon.
Seipin has been shown to play an essential cell-autonomous role in adipogenesis [ 12, 13].
Geminin is an essential cell-cycle protein that is only present from S phase to early mitosis in metazoan somatic cells [ 1, 2].
However, the observation that Gata3 −/− ESCs can contribute to the myeloid and B lineage in adult mice (Ting et al., 1996) argues against an essential cell-autonomous role of Gata3 in the specification of HSCs from their precursors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com