The phrase "an escalation in the frequency of" is correct and usable in written English.
It can be used when discussing an increase in how often something occurs or happens over a period of time.
Example: "There has been an escalation in the frequency of severe weather events in recent years."
Alternatives: "an increase in the occurrence of" or "a rise in the rate of".
Although the overall incidence of grade 2 AEs increased with PX-866 dose escalation, there was no increase in the frequency of grade 3 or 4 AEs.
Following this protocol, the frequency of neutropenia of all grades was significantly higher with dose escalation; however, no significant difference was observed in the frequency of grade 3 or 4 between control arm and dose-escalated arm in this study or other severe toxicities.
In this case parents did not allow further increase in the frequency of the administration or escalation of the dose and asked for a return to the anakinra regimen.
"This is certainly an escalation, albeit a small one in terms of numbers, but an escalation in terms of what Britain is doing there," he said.
Dose escalation was made, in principle, according to the frequency of DLT in the initial four cycles of the therapy at a level, but the toxicity of all cycles was referred to in the determination of the dose level.
The guidelines for an appropriate use of antibiotic therapy recommend de-escalation as soon as the culture sensitivity results are available.There was a great need to study the frequency of de-escalation, no change and escalation of antibiotics and its impact in septic patients in an Indian ICU setting in view of rising burden of drug resistance and health care cost.
The frequency of de-escalation (51% in B+ vs 55% in B- pts) and escalation therapy (19% vs 25%, respectively) was similar in both groups.
The primary measures of interest in this evaluation were the frequency and economic impact of an escalation in biologic dose.
