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Here, we show for the first time that isolated purified mitochondria from the brain of Pink1−/− mice display an enhanced vulnerability to Ca2+-induced Ca2+-induced
Women have an enhanced vulnerability to disease, especially if they are poor.
Previous data have implicated STS in ADHD risk: males with cytogenetic deletions encompassing the gene (or with inactivating mutations within it) appear to show an enhanced vulnerability to the disorder (22 25).
Although our investigation is suggestive that chronic inflammation leads to an enhanced vulnerability to the short-term inflammatory effects of ambient PM, other interconnected aspects of diabetes, obesity, and hypertension may also contribute to the susceptibility of individuals with these disease states.
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The developing brain differs from the adult brain in several different ways, which may provide a physiological basis for any enhanced vulnerability to anaesthetics.
In other words, the former group had more often a stress-event-related onset of OCD compared to the latter group, indexing the possibility that a very stressful birth creates a life-long enhanced vulnerability to stress and an enhanced risk of developing anxiety related symptoms, such as OCD.
Therefore, our findings suggest that the period of rapid synaptogenesis in the monkey is a time of enhanced vulnerability to lead exposure for the appearance of later impairments in sensory regulation.
However, less is known about the long-term neural consequences of chronic EtOH exposure during adolescence, and most importantly whether adolescence represents a developmental period of enhanced vulnerability to such effects.
The disproportionate share of the malaria burden of the República de Panamá that is held by the Guna Amerindians of Comarca Madungandi not only highlights their socially outcast condition but also their likely enhanced vulnerability to malaria, a parasitic disease with transmission that is sensitive to climatic variability.
Only a mutant strain (hm α-Syn-39) presented enhm α-Syn-39erability to neurotoxicants.
Mg2+ antagonizes calcium on the atrioventricular node [ 8] and myocardial Mg2+ deficiency decreases intracellular potassium, resulting in a less negative resting membrane potential and enhanced vulnerability to ventricular arrhythmia [ 9- 11].
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