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We had reported on 68Ga-DOTATOC studies in patients with NETs and an enhanced uptake in metastases of NETs [36].
Confocal microscopy analysis of 6-coumarin-loaded micelles demonstrated an enhanced uptake of EPCL235 and EPCL570 micelles by B16F10 cells compared with non-conjugated micelles, MPCL235 and MPCL570, attributing greater intracellular delivery due to receptor-mediated endocytosis.
We recently demonstrated that agitation during lipoplex formation (vorLTsiR) improves the gene knockdown effect of siRNA because the resultant decrease in lipoplex size leads to an enhanced uptake by cells.
When looking at the tTACs in the monkey brain, an enhanced uptake of [11C]A-844606 walsolsobserveded for approximately 60 min after the injection.
Thus, we hypothesize that the shift in the immune response may be due to an enhanced uptake of luminal contents, including commensal bacteria, through a more structurally damaged and permeable epithelium.
As shown in Figure 6D, treatment of NPA cells with U0126 or Akti IV significantly increased radioiodide uptake and combination of the two inhibitors resulted in an enhanced uptake.
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These findings suggest that it may be possible to bioengineer silicon microparticles to favor opsonization with proteins that enhance uptake by endothelial cells, without a concurrent enhanced uptake by macrophages.
Monocytes responded to LPS, FSL-1, or Pam3CSK4 with a clearly enhanced uptake of the major birch pollen allergen (Fig. 1A).
The tra-genes may provide strain SZ with a mechanism for enhanced uptake of foreign DNA.
The cell- or tissue-specific ligand-receptor interaction contributes to the increased efficacy as a result of enhanced uptake of the complex into tumor cells by receptor-mediated endocytosis.
The presence of the lipids (DPPC, DSPE-PEG, and cholesterol) as the outermost layer and the high rigidity of RNV may lead to an enhanced cellular uptake.[ 1] The cellular uptake of RNV is experimentally tested by co-incubation of RNV loaded with siMDR1 and Dox (RNV[Dox/siMDR1]) and MCF-7/ADR cells for 2 h in medium supplemented with 10%% fetal bovine serum (FBS).
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