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Indeed, all three mutants showed an enhanced propensity to form intracellular aggregates in the absence of proteasome inhibition, with C289G>R275W>R256C (Fig. 7A).
Morphine, in comparison with other opioids, has a high activity-endocytosis ratio, and has an enhanced propensity to prolonging signals with prolonged drug exposure.
The oligomer ensemble seems to have an enhanced propensity (compared with the monomers) for β-sheet nucleation, translating into greatly accelerated formation of the β-sheet-rich fibrils.
Real-time PCR analysis of B-cell lymphoma-extra large (Bclxl) expression gave no indication of an enhanced propensity to apoptosis (Additional file 4A).
Furthermore, transendothelial migration experiments demonstrated an enhanced propensity for circulating TCRζdim T cells to migrate when compared to their TCRζbright counterparts, implying that migration is associated with, and perhaps even facilitated by, loss of TCRζ expression in peripheral lymphoid organs.
It is worth noting that in both confinement types more pronounced peaks of the ρ z) curves correspond to IPCs with relatively bigger patches, indicating an enhanced propensity to form planar structures.
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As a result, longer fibrils in excess of hundreds of nanometers to micrometers have a greatly enhanced propensity towards spontaneous fragmentation and failure.
In the case of the Pin1 WW domain, the answer is clear: replacement of a six-residue loop that is essential for function with shorter sequences with enhanced propensity to form a β turn increases the folding rate by almost an order of magnitude [ 51].
These observations strongly supported the notion of an involvement for Hst-5 in the enhanced propensity of HIV+ individuals to this opportunistic infection [22].
The hypoxic response includes activation of numerous factors associated with cell motility and cytoskeletal structure (Semenza, 2003), and hence Snail-dependent migration is only one of several mechanism suggested to link hypoxia to an enhanced migratory propensity of tumour cells.
Associated pathologies, such as aortic aneurysms and aortic stenosis, may result from either an enhanced intrinsic propensity of the arterial wall to dilate in response to normal biomechanics (Marfan, bicuspid valve), or as a result of pathologic biomechanical load in a given arterial segment.
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