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Consistently, we observed that wild-type cells exposed to cadmium display an enhanced frequency of forward mutations to canavanine resistance and minisatellite destabilisation.
In addition, our data display an enhanced frequency of the ancestral *4 haplotype out of Africa, a feature exhibited by only a subset of genes reported in the literature [for reviews see 33], [34].
Indeed, low calcium bursting was confirmed by intracellular recording showing an enhanced frequency of action potential (Bikson et al., 2002).
Although fetal wastage remained markedly increased when pregnancy occurs, improvements in management have resulted in an enhanced frequency of live births (40 86% of all pregnancies) [ 13– 15].
Here, antagonists may limit B-cell hyper-reactivity and antibody production or mediate immunomodulation or suppression through an enhanced frequency of IL-10 secreting B cells.
With respect to HDs, M/DSFT patients displayed an enhanced frequency of gMDSCs and an increased number of neutrophils in the blood, number that matched the higher plasma arginase activity.
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Moreover, a significantly enhanced frequency of CXCR4-mRNA-positive CD27- naive B cells was found in pSS patients when compared with NHS (36.0% versus 18.1%, P < 0.0001).
It is notable not only that pathogenic autoantibodies are highly mutated but that studies of the BCR repertoire in human SLE demonstrated a diffusely enhanced frequency of somatic hypermutation compared with healthy subjects by using single-cell analysis [ 14- 16, 44].
Despite a housekeeping policy requiring enhanced frequency of cleaning (twice per day) for CDAD patient isolation rooms, C. difficile spores were still detected in approximately 50% of toilets.
A recent analysis of smc5/6 mutants also revealed enhanced frequency of chromosome breakage during an otherwise unperturbed mitotic cell division [ 16].
Upon in vitro antigen stimulation, the leucocytes from INDt were able to shift the down-regulated cytokine profile toward a type 1 modulated pattern, characterized by enhanced frequency of High cytokine producers including IFN-γ from NK-cells and TNF-α and IFN-γ from CD8+ T-cell along with IL-12 and IL-10 from monocytes.
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