Sentence examples for an enhanced efficacy from inspiring English sources

Compared to liposomes, the engineered exosomes (known as iExosomes) target oncogenic KRAS with an enhanced efficacy that is dependent on CD47, and is facilitated by macropinocytosis.

This enhanced anti-arrhythmic effects of combined block of Na+- and K+-channels were also seen in 2D and 3D simulations; specially, there was an enhanced efficacy in terminating re-entrant excitation waves, exerting improved antiarrhythmic effects in the human atria as compared to a single-channel block.

Taking advantage of the combined porosity and magnetic property of the nanohybrid, a photosensitizer chlorin e6 (Ce6) is loaded on MMSN and efficiently delivered into target cells under magnetic guidance, leading to an enhanced efficacy of photodynamic therapy (PDT).

In vitro and in vivo studies demonstrated an enhanced efficacy via synergetic chemo-/radiotherapy.

These circuitry features of the CA1 region lead to an effective electrical shortening of the apical dendritic tree for large EPSPs and in particular to an enhanced efficacy of distal synapses.

In terms of PDR Gram-negative infections, Bulik et al. [84] found that double-carbapenem therapy (ertapenem and doripenem) for carbapenemase-producing K. pneumoniae had an enhanced efficacy over either agent alone both in vitro and in vivo in animal models.

However, the areas to improve on these results include: (a) enhanced efficacy, (b) reduction in the incidence of receptor-negative tumors, (c) improved overall and endocrinological side effects, and (d) improved function on end-organs other than the breast.

(5, 7, 24, 25) While recent improvements in developing new generations of oncolytic Ad vectors with enhanced efficacy and specificity are remarkable, 26 noninvasive monitoring of CRAd replication remains a challenge.

We have previously shown in preclinical xenograft models (including an in vivo CPT-11 resistance model), that EZN-2208 has a significantly enhanced efficacy compared with CPT-11 when both the drugs were compared at their respective maximum tolerated doses [ 14– 16].

Nevertheless, blocking XIAP function by transient overexpression of Smac achieved a promising enhanced efficacy in combination with TRAIL in prostate cancer cell lines [ 46], indicating that XIAP is the predominant target for TRAIL sensitivity.

Chemical agents may augment the viral effects; for example, a calcium blocker, verapamil, and enhanced efficacy of oncolytic Ad administered simultaneously [ 39, 40].